Table 3.

Functional profiling of differentially expressed genes in GK compared to BN rats in adipose tissue (n = 1075) and liver (n = 233) using GENECODIS.

KEGG pathway(s)	Number of genes	Corrected p-value
Adipose tissue
Prostaglandin and leukotriene metabolism	10	0.001
Focal adhesion | ECM-receptor interaction | Hematopoietic cell lineage | Regulation of actin cytoskeleton	4	0.002
ECM-receptor interaction | Hematopoietic cell lineage	5	0.002
ECM-receptor interaction	11	0.002
Glycolysis/Gluconeogenesis	9	0.003
Focal adhesion | ECM-receptor interaction	9	0.003
Arginine and proline metabolism	8	0.005
Glycolysis/Gluconeogenesis | Fructose and mannose metabolism	4	0.005
Glycolysis/Gluconeogenesis | Pentose phosphate pathway | Fructose and mannose metabolism	3	0.012
Hematopoietic cell lineage	9	0.015
Cell Communication | Focal adhesion | ECM-receptor interaction	6	0.019
Fructose and mannose metabolism	6	0.019
Porphyrin and chlorophyll metabolism	5	0.029
Folate biosynthesis	5	0.031
Metabolism of xenobiotics by cytochrome P450	7	0.033
Cytokine-cytokine receptor interaction | Focal adhesion	3	0.033
Focal adhesion	14	0.033
Valine, leucine and isoleucine degradation	6	0.033
Cholera – Infection	5	0.033
Fructose and mannose metabolism | Galactose metabolism	3	0.033
Urea cycle and metabolism of amino groups	4	0.033
Glycine, serine and threonine metabolism	5	0.044
Liver
Arginine and proline metabolism	7	2.17E-06
Alanine and aspartate metabolism | Arginine and proline metabolism	3	2.09E-05
Alanine and aspartate metabolism	4	1.30E-04
Urea cycle and metabolism of amino groups | Arginine and proline metabolism	3	0.0017
Prostaglandin and leukotriene metabolism	4	0.0019
Valine, leucine and isoleucine degradation | Butanoate metabolism	3	0.0030
Fatty acid metabolism	3	0.0103
ECM-receptor interaction	3	0.0361