FIG. 2. Nucleotide sequence of the 5′ region of the human type I InsP3 receptor gene.
Nucleotide numbering is referenced to the +1 nucleotide (A) identified as the major transcription start site (arrow) by primer extension. 5′-RACE termination sites are indicated by asterisks and are located within the GGAGGA high homology region, shown in italics. The putative TATA box (beginning at −39 nt) is overlined in bold. Potential transcription regulatory sites are also overlined and include steroid hormone response element (HRE), CAATT enhancer-binding protein element (C/EBP), AP-1 sites, NF-κB sites, and SRE. The antisense primer (p109a) location used for the primer extension is overlined with a half-arrow. The first intron is indicated by lowercase lettering.