Fig. 7.
Effect of NPY on intracellular cAMP levels. A: Effect of treatment with NPY on the intracellular cAMP levels in primary mouse calvarial osteoblasts cultures. Cells were treated with 10nM NPY for 1 h while the control group received vehicle only. Values represent cAMP levels at days 7 and 14, as assessed by ELISA (n = 2). B,C: Effect of NPY on forskolin-induced intracellular cAMP levels primary calvarial osteoblasts cultures. D: The effect of NPY-Y1 blocker BIB03304 on the regulation of intracellular cAMP levels in primary calvarial osteoblast cultures. Cells were cultured for 7 days and then treated with forskolin alone or with either NPY or NPY-Y1 blocker BIB03304 (values are mean ± SD from three experiments).