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. 2009 Oct 9;4(10):e7403. doi: 10.1371/journal.pone.0007403

Figure 6. TOY attenuates lethality in two sepsis mouse models and is effective in both prophylactic and therapeutic treatments.

Figure 6

(A–D) 20 mg/kg of Fc, TOY3, or TOY8 was given intraperitoneally to mice 30 min before (A) or 1 hr after (B) intraperitoneal administration of LPS (15 mg/kg). The protein is given 1 hr before (C) or 1 hr after (D) generation of CLP. (E and F) 20 mg/kg of Fc or TOY3 was given intraperitoneally to the mice at 1 hr and 12 hr after intraperitoneal administration of LPS (15 mg/kg) (E) or at 1 hr and 12 hr after generation of CLP (F). % Survival represents remaining live mice from total mice (n = 10–11).