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V103 is a buried residue in moss PRFa. A, Primary amino acid sequence of PRFa. The underlined residue is the analogous amino acid that is altered in the fission yeast temperature-sensitive profilin allele. The residue in red is V103, identified by the algorithm of Varadarajan et al. (1996). B, V103 is indicated with a red asterisk in the Kyte-Doolittle hydrophobicity plot. C, PRFa homology model with V103 highlighted. D, PRFa-V103A homology model with Ala highlighted.
