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. 2009 Jul 2;150(10):4502–4511. doi: 10.1210/en.2009-0445

Figure 2.

Figure 2

Restoring hypothalamic ARC leptin receptor signaling improves hepatic insulin action via the hepatic branch of the vagus nerve. Arterial glucose (A) and GIR (B) required to maintain euglycemia during the euglycemic-hyperinsulinemic clamp in obese Koletsky rats that underwent either sham surgery or selective HV and then received Ad-GFP or Ad-LEPR-B directed to the ARC. Rd (C) and the endogenous rate of glucose appearance (Endo Ra) (D) in Ad-GFP- and Ad-LEPR-B-treated animals during the basal (shaded squares) and the clamp period in animals that received sham surgery (open squares) or HV (closed squares). Effect of selective HV compared with sham surgery in animals that received either Ad-GFP or Ad-LEPR-B on percent increase in glucose use (E), percent suppression of hepatic glucose production (F), and hepatic mRNA levels of the gluconeogenic genes G6Pase (G) and Pepck (H) (n = 5–6/group). *, P < 0.05 vs. Ad-GFP-sham.