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. 2009 Jul 2;150(10):4502–4511. doi: 10.1210/en.2009-0445

Figure 3.

Figure 3

ARC-directed leptin receptor gene therapy increases hepatic insulin signal transduction. Effect of ip (10 U/kg) insulin (black bars)-induced activation of tyrosine phosphorylation of IRS-1 (A and C) and serine phosphorylation of PKB/Akt (B and D) compared with vehicle (white bars) in liver and muscle (gastrocnemius), respectively, in obese Koletsky rats 16 d after microinjection of an adenovirus expressing Ad-LEPR-B or the reporter gene, Ad-GFP, that were either fed ad libitum or pair fed to the Ad-LEPR-B-treated animals. Hepatic (E) and muscle (F) triglyceride content in this same group of animals is shown. *, P < 0.05 vs. Ad-GFP; #, P < 0.05 vs. Ad-GFP-PF.