Table 1.
Basal and clamp characteristics in 24-wk-old obese Koletsky rats 7 d after bilateral microinjection of an adenovirus expressing either Ad-LEPR-B or Ad-GFP to the area of the ARC
| Ad-GFP | Ad-LEPR-B | |
|---|---|---|
| n | 5 | 5 |
| Basal | ||
| Δ Body weight (g) | −18.9 ± 3.3 | −22.9 ± 5.2 |
| Food intake (g/d) | 18.2 ± 1.1 | 16.7 ± 1.1 |
| Fat (%) | 41.2 ± 1.0 | 42.2 ± 0.7 |
| Arterial plasma glucose (mg/dl) | 122.0 ± 3.9 | 120.1 ± 3.4 |
| Plasma insulin (ng/ml) | 14.2 ± 4.7 | 11.7 ± 2.3 |
| Plasma leptin (ng/ml) | 161.3 ± 11.5 | 144.7 ± 7.4 |
| Plasma FFAs (mmol/liter) | 1.00 ± 0.14 | 0.90 ± 0.10 |
| Plasma corticosterone (ng/ml) | 806 ± 163 | 677 ± 147 |
| Clamp | ||
| Arterial plasma glucose (mg/dl) | 114.9 ± 3.2 | 124.0 ± 4.7 |
| Plasma insulin (ng/ml) | 27.9 ± 4.5 | 22.9 ± 6.4 |
| Plasma FFA (mmol/liter) | 0.72 ± 0.10 | 0.51 ± 0.06 |
| Plasma corticosterone (ng/ml) | 619 ± 125 | 597 ± 89 |
| GIR (mg/kg · min) | 4.08 ± 0.38 | 5.84 ± 0.57a |
a
, P < 0.05 vs. Ad-GFP.