Table 3.
Change from baseline in score on 11 item cognitive subscale of Alzheimer's disease assessement scale at six months according to apolipoprotein E genotype
| No of copies of E4 allele | Placebo group
|
Galantamine groups
|
P value | |||
|---|---|---|---|---|---|---|
| No of patients* | Mean (SE) change | No of patients* | Mean (SE) change | |||
| Two | 27 | 5.1 (1.1) | 48 | −1.5 (0.7) | 0.0001 | |
| One | 67 | 1.9 (0.6) | 138 | −1.0 (0.5) | 0.0008 | |
| None | 56 | 2.1 (0.9) | 78 | −1.7 (0.7) | 0.0006 | |
*
The low patient numbers reflect the fact that many patients did not give informed consent for apolipoprotein E genotyping.