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Proliferation in E15 control (A, C) and CatnbEx3(cko/+) (B, D) lungs determined by immunostaining with Ki67 antibody. Arrows indicate polyps formed along proximal airways. Panel E indicates ratio of proliferating epithelial cells in the control (C) proximal airways, the none-polyp areas (NP) and the polyps (P) of mutant proximal airways. No statistically significant difference was observed between ratios of “C” and “NP” or “C” and “P”. Scale bar: 80 um.
