Figure 2. Cell-impermeable Hsp90 antagonists inhibit cell invasion.

a, b. T24 cells were treated with the indicated concentration of either DMAG-N-oxide or DMAG and analyzed in a Matrigel invasion assay. c. T24, B16-luc and PC3M cells were treated with DMAG-N-oxide [1 µM] and analyzed as above. d. T24 cells were treated with either normal mouse IgG [20 µg/ml], Hsp90 antibody [20 µg/ml], or DMAG-N-oxide [1 µM] and examined as above. Values represent mean ± SD [n=3].