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. Author manuscript; available in PMC: 2009 Sep 30.
Published in final edited form as: Oncogene. 2007 Oct 29;27(17):2478–2487. doi: 10.1038/sj.onc.1210897

Figure 4. Ex vivo treatment with cell-impermeable Hsp90 antagonists inhibits lung colonization by intravenously administered B16 melanoma.

Figure 4

B16-luc cells were treated with the indicated concentration of DMAG-N-oxide, or with 20 µg/ml normal IgG or Hsp90 antibody. Cells were intravenously or subcutaneously injected into Nu/Nu mice. Bioluminescence was detected following intravenous injection of luciferin using an IVIS Imaging System and was quantified as photons/second using Living Image software [a]. Tumor size following subcutaneous injection was measured three times per week with an electronic caliper [b]. Values represent mean ± SD [a: n=7; b: n=10]. For panel a, p values are as follows: * p< 0.05; ** p< 0.01.

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