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. Author manuscript; available in PMC: 2009 Sep 30.
Published in final edited form as: Curr Biol. 2004 May 25;14(10):885–890. doi: 10.1016/j.cub.2004.03.059

Figure 1. Regulation of Lifespan by Modulating Genes in the TOR Signaling Pathway.

Figure 1

Survival curves on standard laboratory food for male flies obtained after crossing the ubiquitously expressed da-GAL4 enhancer trap with various UAS constructs carrying genes in the TOR signaling pathway ([A]–[E] at 29°C, [F] and [G] at 25°C). All logrank test p values are based on comparison of the overexpressor strain with the driver alone. The plus symbol indicates the parental strain w1118. The mean lifespan (days) of the various genotypes were as follows. (A) da-GAL4/UAS-dTsc1 (closed squares), 29 days (n=136); +/da-GAL4 (driver alone) (open triangles), 26 days (n = 92); +/UAS-dTsc1 (open circles), 25 days (n = 109) (p < 0.0001). (B) da-GAL4/UAS-dTsc2 (closed squares), 29 days (n = 112); +/da-GAL4 (open triangles), 26 days (n = 92); +/UAS-dTsc2 (open circles), 25 days (n = 118) (p < 0.0001). (C) da-GAL4/UAS-dTORFRB (closed squares), 30 days (n = 126); +/da-GAL4 (open triangles), 26 days (n = 92); +/UAS-dTORFRB (open circles), 22 days (n = 98) (p < 0.0001). (D) da-GAL4/UAS-dS6kKQ (closed squares), 30 days (n = 122); +/da-GAL4 (open triangles), 26 days (n = 92); +/UAS-dS6kKQ (open circles), 23 days (n = 115) (p < 0.0001). (E) da-GAL4/UAS-dS6kSTDETE (closed squares), 16 days (n = 75); +/da-GAL4 (open triangles), 26 days (n = 92); +/UAS-dS6kSTDETE (open circles), 24 days (n = 40) (p < 0.0001). (F) da-GAL4/UAS-dTsc2 (closed squares), 69 days (n = 134); +/da-GAL4 (open triangles), 58 days (n = 133); +/UAS-dTsc2 (open circles), 56 days (n = 126) (p < 0.0001). (G) da-GAL4/UAS-dTORFRB (closed squares), 72 days (n = 112); +/da-GAL4 (open triangles), 58 days (n = 133); +/UAS-dTORFRB (open circles), 55 days (n = 128) (p < 0.0001).