Table 3.
Association of rs2046210 with breast cancer risk among Chinese women in the pooled analysis of cases and controls included in all three stages of the Shanghai Studies.
| Genotypes | No of cases | No of controls | OR (95% CI)a | P for trend | |
|---|---|---|---|---|---|
| All women (6,472 cases, 3,962 controls) |
|||||
| GG | 2162 | 1614 | 1.00 (reference) | ||
| AG | 3208 | 1812 | 1.36 (1.24–1.49) | ||
| AA | 1102 | 536 | 1.59 (1.40–1.81) | ||
| Per A allele | 1.29 (1.21–1.37) | 2.0 × 10−15 | |||
| Premenopausal women (3,430 cases, 2,051 controls) |
|||||
| GG | 1135 | 815 | 1.00 (reference) | ||
| AG | 1714 | 953 | 1.30 (1.14–1.47) | ||
| AA | 581 | 283 | 1.54 (1.29–1.84) | ||
| Per A allele | 1.26 (1.15–1.37) | 1.6 × 10−7 | |||
| Postmenopausal women (3,038 cases, 1,906 controls) |
|||||
| GG | 1025 | 798 | 1.00 (reference) | ||
| AG | 1492 | 855 | 1.44 (1.26–1.65) | ||
| AA | 521 | 253 | 1.67 (1.38–2.01) | ||
| Per A allele | 1.33 (1.21–1.45) | 1.1 × 10−9 | |||
| All women (3,654 ER (+) cases, 3,962 controls)b |
|||||
| GG | 1263 | 1614 | 1.00 (reference) | ||
| AG | 1795 | 1812 | 1.33 (1.19–1.48) | ||
| AA | 596 | 536 | 1.52 (1.31–1.35) | ||
| Per A allele | 1.26 (1.17–1.35) | 7.1 × 10−10 | |||
| All women (2,038 ER (−) cases, 3,962 controls)b |
|||||
| GG | 648 | 1614 | 1.00 (reference) | ||
| AG | 1022 | 1812 | 1.45 (1.28–1.65) | ||
| AA | 368 | 536 | 1.75 (1.47–2.08) | ||
| Per A allele | 1.35 (1.24–1.46) | 4.2 × 10−12 | |||
a
Adjusted for age, education, study stage, body mass index, age at menarche, and age at first birth.
b
Compared to cases with ER (+) cancer, adjusted ORs (95% CI) for ER (−) cancer were 1.00 (reference), 1.10 (0.998–1.25), and 1.20 (1.02–1.42), respectively for genotypes GG, AG, and AA (p for trend, 0.02).