Figure 9.

Sleep restriction did not affect acquisition of a hippocampal-dependent appetitive, paired associates learning task used to assess episodic memory. Mice learned that one of two odor cues was rewarded in one context, and that in another context the reward assignment was reversed. After training, acquisition of a new odor/context pair was then tested during 5 d of the 4 h TM-on, 2 h TM-off sleep restriction condition. There was no difference in performance (percentage of correct trials) between groups (white/black bars); however, both genotypes showed significant improvement across days (gray cross-hatched bars). Error bars indicate SEM.