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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2009 Sep 1;8(9):2509–2516. doi: 10.1158/1535-7163.MCT-09-0386

Figure 4.

Figure 4

Triptolide induces the death of both quiescent and proliferating CD34+ cells from patients with CML. Profiles of CFSE-labeled cells from patients with CML were shown on the left panel. Shaded area represents proliferation profile at the time of annexin V assay while open area shows the fluorescence profiles of cells before starting the culture. Cells were cultured with growth factors or co-cultured with MS-5 cells for 4-7 days and then treated with triptolide for 24 or 48 hours. Apoptosis in quiescent and proliferating CD34+ cells was determined using annexin V staining and shown as % positivity of the respective populations. GF, growth factor; P, proliferating; Q, quiescent.