Fig 1.

18q loss of heterozygosity (LOH) in colorectal cancer. (A) Smoothing spline plot of odds ratio (OR) for 18q LOH in non–microsatellite instability (MSI) –high colorectal cancer according to body mass index (BMI) (left panel) and LINE-1 methylation level (right panel). Patients with low BMI or with high-level LINE-1 methylation were used as a reference group; 95% CIs are indicated by blue dashed lines. (B) Kaplan-Meier curves for colorectal cancer–specific survival (top panel) and overall survival (bottom panel) according to 18q LOH status in non–MSI-high colorectal cancer.