Table 2.

Multivariate Analysis of the Relations With 18q LOH in 555 Non–MSI-High Colorectal Cancers

Variable Independently Associated With 18q LOH	Multivariate OR	95% CI	P
JC virus T antigen	1.93	1.19 to 3.13	.0077
BMI ≥ 30 kg/m2v < 30 kg/m2	2.01	1.15 to 3.52	.014
High tumor grade v low grade	0.40	0.19 to 0.86	.018
KRAS mutation	0.66	0.44 to 0.98	.040
LINE-1 hypomethylation, 30% decrease as a unit	1.92	1.02 to 3.62	.045

NOTE. The multivariate logistic regression model included age, sex, family history of colorectal cancer, tumor location, stage, MSI (low v microsatellite stability), CIMP, BRAF, PIK3CA, p53, β-catenin, and the variables listed in the table.

Abbreviations: LOH, loss of heterozygosity; MSI, microsatellite instability; OR, odds ratio; JC, John Cunningham; BMI, body mass index.