Figure 2.

Schematic overview of identified fusion kinases. Summary of the different PTKs identified in the different screens, each based on the use of a specific retroviral construct. 3′-RACE followed by sequence analysis was used to determine the presence of a fusion gene involving the dimerization domain and to identify the partner gene. The ETV6 and EML1 dimerization domains are presented with the black box, the tyrosine kinase part present in the identified fusion and its kinase domain are shown with the gray and white boxes, respectively.