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Therapeutic efficacy of EZN-2208 in a xenograft model of NHL (Raji). CB17 SCID mice (6–10 mice per group) were inoculated i.v. with 2.5×106 Raji cells per mouse. After one day, mice were treated with either a single (qd×1) or multiple (q2d×5) injections of EZN-2208 or CPT-11 at MTD. (A) Single MTD doses: Control (▪), EZN-2208 at 30 mg/kg (▴), CPT-11 at 60 mg/kg (○) (B) Multiple MTD doses (q2d×5): Control (▪), EZN-2208 at 10 mg/kg (▴), CPT-11 at 40 mg/kg (○).
