Table 7.
Monitoring AL amyloidosis in 39-year-old male with amyloidogenic κ free light chains (FLC) by FLC immunoassay, and serum and urine protein electrophoresis.
| Date of sample collection | κFLC IMMAGE a(mg/L) | κFLC BNII b(mg/L) | SPEP IgG κ (g/L) | UPEP κBJP (mg/24h) |
|---|---|---|---|---|
| 12/8/04 (At time of diagnosis) | 560 | 654 | 4 | 24 |
| 30/08/04 (Post 7 days treated) | 118 (54) | 143 | - | - |
| 20/09/04 | 239 | 352 | 4 | 34 |
| 22/10/04 | 146 (62) | 199 | 3 | 30 |
| 7/02/05 | 81 (38) | 85 | 3 | 27 |
| 16/05/05 * | 110 (54) | 185 * | 4 | 27 |
| 15/08/05 | 100 (−) | - | - | - |
| 14/11/05 ** | 210 (109) ** | - | - | - |
| 24/11/05 (Date of ASCT) | - | - | - | - |
| 1/12/05 | 57 (28) | 42 | 5 | 33 |
| 29/05/06 | 62 (39) | 51 | 3 | 15 |
| 28/08/06 | 70 (33) | 62 | 3 | Trace by IFE |
a
κFLC measured over several reagent lots by IMMAGE; concentrations shown in brackets are at initial 1 in 10 dilution; final concentrations are at 1 in 50 or higher dilution;
b
κFLC measured retrospectively by BNII using one reagent lot; samples with κFLC >160 mg/L went on to the next higher sample dilution.
*
FLC progress detected by BNII
**
FLC progress detected by IMMAGE; ASCT; autologous stem cell transplantation; BJP, Bence Jones protein; IFE, immunofixation electrophoresis; SPEP, serum protein electrophoresis; UPEP, urine protein electrophoresis.