Table 1.
Baseline characteristics of men with colorectal cancer and male controls*
| Cases | Controls | P value | |
|---|---|---|---|
| N | 197 | 371 | |
| Age at randomization, y† | 56 (51–61) | 56 (50–59) | Matched |
| Smoking status, N (%) | Matched | ||
| Past | 94 (48) | 178 (48) | |
| Current | 19 (10) | 33 (9) | |
| Follow-up years, y† | 10 (6–13) | 10 (6–13) | Matched |
| Age at diagnosis, y† | 64 (59–70) | - | |
| Tumor site, colon, N (%) | 147 (75) | - | |
| Fasting time < 8 hours, N (%) | 145 (78) | 262 (76) | 0.53 |
| Current multivitamin use, N (%) | 38 (19) | 75 (20) | 0.75 |
| Aspirin assignment, N (%) | 96 (49) | 194 (52) | 0.47 |
| Body mass index ≥ 25 kg/m2, N (%) | 94 (48) | 154 (42) | 0.24 |
| Alcohol intake ≥ 1 drinks/day, N (%) | 59 (30) | 102 (28) | 0.62 |
| Red meat intake ≥ 1 servings/day, N (%) | 47 (24) | 101 (28) | 0.42 |
| Dairy food intake ≥ 1 servings/day, N (%) | 102 (52) | 201 (54) | 0.54 |
| Fish intake ≥ 2 servings/wk, N (%) | 86 (44) | 168 (46) | 0.59 |
| Cold cereal intake ≥ 2 servings/wk, N (%) | 100 (51%) | 160 (43%) | 0.09 |
| Vigorous exercise ≥2 times/wk, N (%) | 106 (54) | 216 (59) | 0.26 |
| Plasma biomarkers† | |||
| Pyridoxal 5′-phosphate (PLP), pmol/ml | 65 (50–90) | 70 (52–103) | 0.14 |
| Folate, ng/ml | 5 (3–7) | 5 (3–7) | 0.79 |
| Vitamin B12, pg/ml | 434 (374–575) | 467 (364–572) | 0.93 |
| Homocysteine, nmol/ml | 11 (9–13) | 10 (8–13) | 0.13 |
| C-reactive protein, mg/l | 1 (0.5–2) | 1 (0.5–2) | 0.54 |
| Tumor necrosis factor receptor-2, pg/ml | 2,368 (1,986–2,790) | 2,244 (1,917–2,629) | 0.10 |
| Interleukin-6, pg/ml | 1 (0.8–2) | 1 (0.7–2) | 0.19 |
*
All P values > 0.05. P values were calculated using the Mantel-Haenszel test for categorical variables and the paired t-test performed on loge-transformed plasma biomarker levels.
†
Median (25th – 75th percentile)