. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Ann N Y Acad Sci. 2008;1135:43–51. doi: 10.1196/annals.1429.040

TABLE 4.

Causes of secondary amenorrhea^a

Category	Approximate frequency (%)
Low or normal FSH	66
Weight loss/anorexia
Nonspecific hypothalamic causes
Chronic anovulation, including PCOS
Hypothyroidism
Cushing syndrome
Pituitary tumor, empty sella, Sheehan syndrome
Gonadal failure: high FSH	12
46,XX
Abnormal karyotype
High prolactin level	13
Anatomic	7
Asherman's syndrome
Hyperandrogenic states	2
Ovarian tumor
Non-classic CAH
Undiagnosed

From the ASRM Practice Committee.¹⁹