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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Trends Neurosci. 2009 Aug 26;32(9):485–495. doi: 10.1016/j.tins.2009.05.007

Table 1.

Physiological roles of DISC1 and NRG1/ErbB4 cascades at various stages of neurodevelopment, which seem to be disturbed in schizophrenia.

Stage Process DISC1 NRG1/ErbB4 Major References
Pre/perinatal period
(Cortex)		 Progenitor cell proliferation +++ ++ [56, 85]
Radial migration +++ ++ [66, 88]
Tangential migration ND +++ [89]
Neurite outgrowth/ arborization ++ ++ [75, 92]
Astrogenesis ND +++ [93]
Postnatal maturation
(Cortex)		 Interneuron maturation ND ++ [99]
Dopaminergic neuron
maturation		 ND + [96]
Glutamatergic synapse
maturation/pruning		 + ++ [79, 94]
Oligodendrocyte development/
Myelination		 + ++ [59, 96, 98]
Adulthood Neurogenesis (Hippocampus) +++ ND [56, 58]
Neuronal plasticity ND ++ [94]
cAMP signaling ++ ND [60]

The roles of these two cascades in the pre/perinatal period, postnatal maturation, and adulthood are summarized. +++, well-established observation, including verification with in vivo models; ++, strongly indicated; +, suggested; ND, not addressed yet.