Table 2.
Summary of statistical analyses for asenapine and apomorphine effects on prepulse inhibition
| Factor | Low-dose Asenapine | High dose Asenapine | |
|---|---|---|---|
| Startle magnitude | Asenapine | F(5,54) = 2.48, P < 0.05 | NS |
| Apomorphine | NS | F(1,54) = 10.62, P < 0.002 | |
| Asenapine × Apomorphine | NS | F(5,54) = 3.09, P < 0.02 | |
| Habituation | Trial block | F(1,54) = 67.06, P < 0.0001 | F(1,54) = 80.76, P < 0.0001 |
| Apomorphine | NS | NS | |
| Asenapine × apomorphine | F(5,54) = 3.37, P < 0.02 | F(5,54) = 3.64, P < 0.007 | |
| Asenapine × trial block | NS | F(5,54) = 2.76, P < 0.03 | |
| Asenapine × apomorphine × trial block | F(5,54) = 3.18, P < 0.015 | NS | |
| Prepulse inhibition | Asenapine | F(5,54) = 3.01, P < 0.02 | F(5,54) = 3.29, P < 0.015 |
| Apomorphine | F(1,54) = 59.67, P < 0.0001 | F(1,54) = 15.68, P < 0.0003 | |
| Prepulse intensity | F(2,108) = 74.32, P < 0.0001 | F(2,108) = 185.35, P < 0.0001 | |
| Asenapine × apomorphine | F(5,54) = 8.74, P < 0.0001 | F(5,54) = 9.53, P < 0.0001 | |
| Asenapine × prepulse intensity | F(10,108) = 4.54, P < 0.001 | F(10,108) = 3.35, P < 0.001 | |
| Apomorphine × prepulse intensity | F(2,108) = 20.02, P < 0.0001 | F(2,108) = 8.39, P < 0.0005 | |
| Apomorphine × trial block | F(1,54) = 4.38, P < 0.05 | NS | |
| Asenapine × × trial block | F(5,54) = 4.00, P < 0.004 | NS | |
| Trial block × prepulse intensity | NS | F(2,108) = 8.41, P < 0.0005 | |
| Asenapine × apomorphine × prepulse intensity | F(10,208) = 1.94, P < 0.05 | NS | |
| Asenapine × prepulse intensity × trial block | F(10,108) = 2.13, P < 0.03 | NS |
NS not significant