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Candidate sites for modulation of aberrant networks
| Cellular target | Candidate site | Clinical efficacy | Status |
|---|---|---|---|
| Pyramidal cell | mGluR2/3 ( +) | high | Phase IIb clinical |
| NR2B (−) | – | Early clinical | |
| α2 GABAA (+) | – | Early clinical | |
| α5 GABAA (+) | Preclinical | ||
| Interneuron | D1 (+) | – | Early clinical |
| Astrocyte | PAR1 (−) | – | Preclinical |
| mGluR1/5 (−) | – | Preclinical |
Negative sign (−) antagonist, positive sign (+) agonist/positive modulator
