Table 1.

General health status, diagnosed depression and CES-D scores by the PON1 Q192R genotype in individuals aged between 60 and 79 years, with additive and per-allele age and sex-adjusted logistic regression results

	PON1 genotype			Additive logistic regression results, age, sex adjusted		Per-allele logistic regression results, age, sex adjusted (RR compared with QQ = 1)
	QQ	QR	RR	OR (95% CI)	P-value	OR (95% CI)	P-value
ELSA	n = 1582 (50.1%)	n = 1302 (41.2%)	n = 274 (8.7%)
Self-reported general health (% reporting fair to very poor)	28.3	27.93	32.35	1.05 (0.93–1.18)	0.42	1.21 (0.92–1.60)	0.18
Any history of diagnosed depression (% diagnosed)	5.75	5.45	6.57	1.03 (0.82–1.30)	0.80	1.17 (0.69–1.31)	0.55
CES-D score (8-point scale) [mean (SD)]	1.36 (1.80)	1.39 (1.86)	1.36 (1.68)
% depressed (using CES-D ≥3 as symptomatic of depression)	19.2	19.7	19.8	1.04 (0.90–1.19)	0.61	1.06 (0.77–1.48)	0.71
% depressed (using CES-D ≥4 as symptomatic of depression)	12.4	12.4	13.2	1.03 (0.87–1.21)	0.74	1.09 (0.74–1.61)	0.65
InCHIANTI	n = 368 (48.4%)	n = 337 (43.3%)	n = 56 (7.4%)
Self-reported general health (% reporting fair to very poor)	36.5	37.8	24.1	0.86 (0.67–1.10)	0.23	0.55 (0.28–1.08)	0.08
CES-D (60-point scale) [mean (SD)]	11.70 (8.50)	11.98 (8.12)	9.85 (8.32)
% depressed (CES-D≥16)	17.3	17.7	14.8	0.94 (0.68–1.30)	0.71	0.86 (0.38–1.96)	0.72
Meta-analysis	n = 1950 (49.8%)	n = 1639 (41.8%)	n = 330 (8.4%)
Self-reported general health (% reporting fair to very poor)	29.9	30.0	31.0	1.01 (0.91–1.13)*	0.80*	1.06 (0.82–1.37)*	0.63*
% above study specific CES-D cut-off points	13.3	13.5	13.5	1.01 (0.87–1.17)*	0.90*	1.04 (0.73–1.47)*	0.84*

^*Adjusting for study also in meta-analysis.

SD = standard deviation.