Table 4.

Adjusted HRs for various categorizations of NSAID use

	N	PY	AD	aHR (95% CI)
Model 1*
No NSAID	9,501	47,293	642	1.0
SALA alone	2,544	14,828	127	0.82 (0.67 – 0.99)
Non-SALA alone	743	4,162	25	0.60 (0.40 – 0.90)
Both SALA & non-SALA	573	3,704	23	0.87 (0.57 – 1.33)
Unclassifiable alone	96	556	3	0.61 (0.19 – 1.89)
Model 2*
No NSAID	9,501	47,293	642	1.0
Any ibuprofen	2,093	12,731	103	0.88 (0.71 – 1.09)
Other than ibuprofen	1,863	10,518	75	0.67 (0.53 – 0.86)
Model 3*
No NSAID	9,501	47,293	642	1.0
Any naproxen	806	4,887	22	0.55 (0.36 – 0.85)
Other than naproxen	3,150	18,363	156	0.82 (0.69 – 0.99)

aHR=adjusted hazard ratio, N=number, PY=person years, AD=incident Alzheimer’s dementia, CI=confidence interval, NSAID=non-steroidal anti-inflammatory drug, SALA=selective Aβ₄₂-lowering agent

Each model shows the relationship between a medication classification and the risk of incident AD. All models are stratified by study and adjusted for age, sex, and education. The variables shown within each model are mutually exclusive categorizations of the medication exposure of interest.

^*Data on NSAID type missing for 42 participants