FIGURE 2.
Number of papers that included use of tumor ROIs, as function of year of publication. Papers were identified by Medline search that queried for FDG AND SUV OR “standard uptake value” OR “standardized uptake value” OR “standardised uptake value”). Only human 18F-FDG oncology studies were included. ROI max refers to maximal pixel in tumor. ROI peak refers to small (typically 15 × 15 mm) fixed-size ROI centered on most metabolically active part of tumor. ROI isocontour refers to irregular ROI defined by isocontour set at, for example, some percentage of maximal pixel. ROI manual refers to manually drawn ROI. Only a subset of these papers describes response assessment studies.