Table 3.

Results of Regression Analyses of Prognostic Factors for Disease-Specific Survival by Lymph Node Dissection Region

	Neck (n = 626)			Axillary (n = 762)			Inguinal (n = 960)
	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P	Hazard ratio	95% CI	P
Minimal LN ratio threshold			< .001			< .001			< .001
< threshold v > threshold	0.53	0.40–0.71		0.52	0.42–0.65		0.47	0.36–0.61
Clark Level			NS			NS			.056
IV – V v II – III	1.46	0.91–2.36		1.20	0.86–1.66		1.56	1.28–3.75
Unknown v II – III	1.66	0.98–2.82		1.17	0.79–1.73		1.79	1.08–2.98
Histologic type			NS			0.041			NS
Nodular v superficial spreading	1.32	0.88–1.97		1.40	1.02–1.94		1.29	0.88–1.90
Other/unknown v superficial spreading	1.03	0.71–1.50		1.06	0.78–1.44		1.15	0.80–1.66
Primary tumor ulceration
Yes v no	1.32	0.94–1.84	NS	1.26	0.97–1.64	NS	1.44	1.07–1.94	.016

Abbreviations: CI, confidence interval; LN, lymph node; NS, not significant.

Note: All hazard ratios were adjusted for age (≥ 50 v < 50 years), sex, year of diagnosis (2003–2005 v 1988–1997, 1998–2002 v 1988–1997), geographic region, and T stage.

Disease-specific survival (DSS) for the neck and inguinal regions were calculated using Cox proportional hazard models, while DSS for the axilla region was calculated using a log-normal parametric model.