Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reaction coordinate (schematic) for spontaneous base pair opening in B DNA through a 180° rotation along a major groove pathway as determined in potential of mean force calculations [9–11]. Characteristic opening equilibria (kop/kcl), and opening and closing rates (kop and kcl) for G:C and A:T base pairs are noted (T = 15 °C) [15,17]. The bracket denotes a population of isoenergetic out conformations that are in rapid fluctation.
