Table 1. Compilation and major features of the RNA modification guides described in this study.
| Name | Family | RNA target (human) | Antisense element | snoRNA host gene (human) | Accession no. |
|---|---|---|---|---|---|
| U94 | C/D | Cm62 (U6) | 13 bp/D | FLJ20758 (intron 21), conserved hypothetical protein | AY349593 |
| U95a | C/D | Am2792/Cm2801 (28S) | 13 bp/D + 10 bp/D′ | GNB2L1 (intron 1), guanine nucleotide-binding protein (G protein) | AY349594 |
| U96aa,b | C/D | Gm75 (5.8S) | 12 bp/D | GNB2L1 (intron 2) | AY349595 |
| U96b | C/D | Gm75 (5.8S) | 12 bp/D | AMMECR1 (intron 2), unknown function | AY349596 |
| U97 | C/D | ND | EIF4G2 (intron 14), translation initiation factor | AY349597 | |
| U98a | H/ACA | ND | ND | LOC85028 (intron 2), poorly characterised gene | AY349598 |
| U98b | H/ACA | ND | PPP2R5A (intron 8), protein phosphatase 2, regulatory subunit B | AY349599 | |
| U99 | H/ACA | ND | MGC2477 (intron 3), conserved hypothetical protein | AY349600 | |
| U100 | H/ACA | U9? (U6)c | (6 + 4)/3′ hairpin | FLJ20516 (intron 6), homologous to Tipin | AY349601 |
| U101 | C/D | ND | RPS12 (intron 3), ribosomal protein | AY349602 | |
| U102 | C/D | Gm4010 (28S) | 11 bp/D | RPL21 (intron 2), ribosomal protein | AY349603 |
| U103ad | C/D | Gm601 (18S) | 10 bp/D′ | PUM1 (intron 17), RNA-binding protein (Pumilio family member) | AY349604 |
| U103bd | C/D | Gm601 (18S) | 10 bp/D′ | PUM1 (intron 21) | |
| U104a | C/D | Cm1320 (28S) | 14 bp/D′ | Not annotated gene | AY349605 |
| U105 | C/D | Um799 (18S) | 15 bp/D | SSF1 (intron 3), Peter Pan homologue (contains a Brix domain) | AY349606 |
| U106 | C/D | G1536?/U1602? (18S)c | 10 bp/D + 10 bp/D′ | BC032480 (intron 1), poorly characterised gene | AY349607 |
aU95, U96 and U104 sequences have been independently submitted in the public database as: Z38, Z37 and Z12 snoRNAs, respectively.
bU96 might be the mammalian counterpart of the A.thaliana Z37a and Z37b snoRNA involved in Gm79 formation in A.thaliana 5.8S rRNA (24).
cA question mark means that no Ψ9 or Gm1536 and Um1602 have been detected in human U6 snRNA and 18S rRNA, respectively.
dU103a and U103b RNAs target the same rRNA position as MBII-251 and thus might be considered as snoRNA isoforms of the latter.