Table 2.

Activation Energies for Oxidation Reactions of P450 Compounds I.^a

Substrate	BDE (kcal/mol)	P450	Ea (kcal/mol)
lauric acidb	98	CYP119	17.9
cyclopropylmethylc	95	CYP119	16.4
	95	CYP2B4	16.3
benzphetamimed	89	CYP119	15.7
	89	CYP2B4	15.5
styrene		CYP102HD	15.2
		CYP119	14.6
benzyl alcohole	79	CYP119	13.7

^aThe data for hydroxylation activation energies and hydrocarbon BDEs are from ref (17); the styrene activation energies are from this work.

^bUnactivated CH positions in lauric acid.

^cCH of methyl group adjacent to cyclopropyl ring.

^dCH of the methyl group adjacent to amine nitrogen.

^eBenzylic CH position in benzyl alcohol.