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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Cancer Res. 2009 Jun 23;69(13):5312–5320. doi: 10.1158/0008-5472.CAN-08-3767

Figure 3. Constitutive activation of the Notch1 pathway enhances melanocyte growth in vitro.

Figure 3

A, (Left) mRNA analysis of Notch1 expression in GFP- and NIC-infected FOM 117 cells by RT-PCR. (Right) Western blot analysis of Notch1 protein expression in GFP and NIC-infected FOM 117 cells.

B, Immunofluorescence analysis of NIC localization in FOM 117 GFP and NIC-infected cells.

C, mRNA expression of Hey1 and Hey2 in FOM 117 GFP and NIC-infected cells as determined by quantitative RT-PCR.

D, ∼ 2 week growth curve of GFP- and NIC-infected FOM 123 and 124 cells. *p<0.005 (Student's T-test).