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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Cancer Res. 2009 Jun 23;69(13):5312–5320. doi: 10.1158/0008-5472.CAN-08-3767

Figure 6. Notch1 activation transforms primary melanocytes in vitro.

Figure 6

A, Constitutive Notch1 activation induces focus formation in NIC-infected melanocytes grown in monolayer on tissue culture dishes. *p<0.005 (Student's T-test).

B, NIC-infected melanocytes display increased survival in limiting growth factor conditions, as depicted. 100% media indicates normal melanocytes media containing bFGF, SCF, and ET3. 10% media is a 10-fold decrease in FBS; the growth factor(s) present in each respective medium is described beneath each panel. *p<0.005 (Student's T-test).

C, NIC-infected melanocytes display anchorage-independent growth in soft agar. *p<0.005 (Student's T-test).