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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Arch Toxicol. 2009 Jun 21;83(10):909–924. doi: 10.1007/s00204-009-0450-y

Figure 1.

Figure 1

Simplified biotransformation pathways of N-EtFOSE: PFOS is the major metabolite of N-EtFOSE detected in the liver and serum of female rats. Several other metabolites, including FOSA and N-EtFOSAA, were also detected in agreement with the N-EtFOSE biotransformation pathway proposed by Xu and co-workers (Xu et al., 2004). Major metabolites are shown in bold. Metabolites shown in parentheses were either not detected (N-EtFOSA) or not analyzed (FOSAA). O- and N-glucuronide metabolites are omitted for clarity reasons. N-EtFOSE was administered orally over a three week period, animals were euthanized on day 21 and liver and serum samples were analyzed for selected metabolites as described under Materials and Methods. The chemical names of the metabolites are listed under Methods and Materials.