Scheme 2.
Synthesis of protected 6-azidopenicillanic acid. Conditions: (a) TfN3, Et3N, CH2Cl2/MeOH/H2O, rt, (b) TfN3, Et3N, DMAP, rt, 2–2.5 hrs, (c) TfN3, Et3N, toluene, rt, 1.5–2.5 hrs.
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