. Author manuscript; available in PMC: 2009 Oct 2.

Published in final edited form as: Int J Hyperthermia. 2008 Feb;24(1):79–90. doi: 10.1080/02656730701840147

Table II. Chemodosimetry with liposomally-encapsulated contrast agents.

Therapies	Imaging modalities	Groups	Timepoints (post-injection)	Results	Reference
TSL, thermosensitive liposomes; NTSL, non-thermosensitive liposomes.
Gd-TSL, HT	MRI	TSL + HT	20 min	Strong T1 effect visible after liposomal heating in 4/6 animals	31
^99mTc-lip, HT	Planar scintigraphy	1. ^99mTc-lip + HT	120, 240, 480 min	2-13-fold increase in liposome accumulation w/ HT (p = 0.001)	10
		2. ^99mTc-lip-HT
Gd-NTSL, rhodamine-NTSL	MRI	1. Gd-NTSL vs. rhodamine-NTSL into primate brain	∼ 20 min (?)	Imaging of Gd-NTSL was ‘highly accurate at determining tissue distribution’ compared to histologic analysis of rhodamine-NTSL distribution	32
		2. Real-time Gd-NTSL into primate brain
^99mTc-lip, Doxil (NTSL), HT	PET	1. Doxil + HT	5 h, 18 h	HT increased intratumoral ^99mTc (p = 0.0006); positive correlation between [^99mTc] and [doxorubicin] in both HT and unheated groups (Pearson's = 0.92)	11
		2. Doxil-HT
		3. ^99mTc-lip + HT
		4. ^99mTc-lip-HT
		5. ^99mTc-lip + Doxil + HT
		6. ^99mTc-lip + Doxil - HT
MnSo₄-Dox liposomes, HT	MRI	1. NSTL + HT	0, 5 min, 30 min, 90 min	1. Rapid + stable peripheral enhancement	34
		2. NTSL - HT		2. More uniform enhancement
		3. TSL + HT		3. Intermediate between 1 and 2
		4. TSL - HT		4. Minimal enhancement
MnSo₄-Dox liposomes, HT	MRI	1. NSTL + HT	45 min	Positive correlation between HPLC and histologic fluorescence estimate of [DOX] and T1-based estimate	35
		2. NTSL - HT
		3. TSL + HT
		4. TSL - HT
MnSo₄-Dox liposomes, HT	MRI	1. TSL prior to HT	During treatment, 60 days	1. Central drug distribution	36
		2. TSL during HT		2. Peripheral drug distribution; highest/fastest intratumoral concentration and longest growth delay
		3. TSL prior to and during HT		3. Uniform drug distribution