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Pharmacokinetics (PK) parameters [ ± standard error (SE)] from the population analysis
| Parameter estimate | SE of estimate | |
|---|---|---|
| CL/F (L/h) | 3.4 | 0.17 |
| Vd/F (L) | 79.2 | 6.6 |
| Ka (/h) | 0.42 | 0.11 |
| Inter-patient variability | ||
| CL/F (%) | 35 | |
| Ka (%) | 139 | |
| Residual variability | ||
| Proportional (%) | 8 | |
| Additive (mcg/mL) | 0.46 |
CL/F, apparent clearance; Ka, absorption rate constant; Vd/F, apparent volume of distribution.
