TABLE 1.

Median (Range) Lopinavir, Ritonavir, and Efavirenz Pharmacokinetics

	Cmax (mg/L)	Tmax (hr)	t1/2 (hr)	Cmin (mg/L)	AUCτ (mg × hr/L)	V (L)	CL (L/h)
LPV	12.0 (1.5–36.6)	3.0 (2.0–11.8)	9.3 (4.6–19.1)	6.3 (0.7–25.1)	100.2 (13.4–318.5)	26.8 (8.7–177.9)	2.4 (0.57–20.25)
RTV	1.0 (0.04–3.7)	3.0 (1.0–8.1)	4.5 (3.1–8.2)	0.3 (0.01–1.2)	6.6 (0.3–28.9)	69.1 (16.2–1708)	11.8 (2.0–264.8)
EFV	3.57 (1.4–7.6)	3.0 (2.0–11.9)	9.94 (4.9–27.8)	0.77 (0.2–2.5)	40.87 (13.7–86.2)	104.76 (64.0–343.0)	8.5 (2.3–22.9)

AUC_τ was AUC₁₂ for LPV and AUC₂₄ for EFV.

C_min was C_{12 h} for LPV and estimated C_{24 h} (EstC_{24 h}) for EFV.