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Single-channel recordings from wild type α4β2 (conventional expression) and the F3-Trp mutant (nonsense suppression) at site B, with nicotine applied at EC50 values (0.080 and 1.2 µM, respectively). Lower traces are expansions of the regions marked by a bar in the upper trace. Records were obtained in the cell-attached configuration with a pipette potential of +100 mV and are shown at 2 kHz bandwidth. Channel openings are shown as downward deflections.
