Fig. 1.

Effect of WIN on MPTP-induced loss of TH⁺ neurons in the SNc. Saline or MPTP (4x 20 mg/kg, i.p.) were administered every 2 hr on day 0 to CB₁^+/+ mice. Vehicle or WIN (1 mg/kg, i.p. or 4 mg/kg, i.p.) were administered every day over a 5 day period, starting 24 hr after the last injection of saline or MPTP. Animals were sacrificed on day 7. (A) Representative microimages of midbrain immunostained for TH (scale bar = 100 μm). (B) Unbiased stereological quantification of TH⁺ neurons in the SNc. ^###p<0.001 compared to saline-treated control; *p<0.05 as shown (ANOVA followed by Bonferroni’s multiple comparisons post-test; n=5 per treatment).