Fig. 2.
Measurement of DA and DOPAC levels and DA turnover (DOPAC/DA) in the dorsal striatum (A) and ventral midbrain (B). Saline or MPTP (4x 20 mg/kg, i.p.) were administered every 2 hr on day 0. Vehicle or WIN (4 mg/kg, i.p.) were administered every day over a 5 day period, starting 24 hr after the last injection of MPTP. Animals were sacrificed on day 7 post-MPTP treatment. *p<0.05 and **p<0.01 compared to saline+vehicle; #p<0.05 compared to MPTP+vehicle (ANOVA followed by Newman-Keuls’ multiple comparisons post-test; n=4 per treatment).