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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Peptides. 2009 Jun 27;30(10):1866–1873. doi: 10.1016/j.peptides.2009.06.021

Figure 5.

Figure 5

Effects of Dynamin 2 and Scamp 2 on insulin secretion from Beta-TC6 cells. Panel A shows knockdown of Dynamin 2 and Scamp2 by their respective siRNAs (D and S) compared to a control (C) scrambled siRNA. Panel B shows effects of siRNA to Scamp2 and Dynamin 2 on glucose stimulated insulin secretion and on the inhibitory response to enterostatin. Panel C shows that a transfected Dominant Negative Dyn2 (K44A) construct (DN) inhibits insulin secretion and blocks any further inhibitory effect of enterostatin on insulin secretion. Values represent Means ± SEMs for a minimum of 4 observations/group. *** p<0.001 compared to controls or groups as shown.