Table 1.
Genes involved in Protein Trafficking in response to Enterostatin
| Gene Name | Symbol | GT1-7 | HepG2 |
|---|---|---|---|
| ARP1 actin-related protein 1 homolog A (yeast) | Actr1a | nd | down |
| annexin A7 | Anxa7 | up | nd |
| adaptor protein complex AP-1, beta 1 subunit | Ap1b1 | up | nd |
| adaptor protein complex AP-1, gamma 1 subunit | Ap1g1 | down | down |
| adaptor protein complex AP-1, gamma 2 subunit | Ap1g2 | down | down |
| adaptor protein complex AP-1, sigma 1 | Ap1s1 | up | nd |
| adaptor-related protein complex 2, beta 1 subunit | Ap2b1 | up | nd |
| adaptor-related protein complex 3, sigma 1 subunit | Ap3s1 | up | nd |
| adaptor-related protein complex AP-4, mu 1 | Ap4m1 | down | nd |
| ADP-ribosylation factor 1 | Arf1 | down | up |
| ADP-ribosylation factor 5 | Arf5 | down | nd |
| ADP-ribosylation factor 6 | Arf6 | down | up |
| Rho guanine nucleotide exchange factor (GEF) 1 | Arhgef1 | down | nd |
| ADP-ribosylation factor-like 2 | Arl2 | down | up |
| ADP-ribosylation factor-like 6 | Arl6 | nd | up |
| blocked early in transport 1 homolog (S. cerevisiae) | Bet1 | down | nd |
| choroidermia | Chm | up | nd |
| clathrin, light polypeptide (Lca) | Clta | up | down |
| component of oligomeric golgi complex 2 | Cog2 | up | nd |
| coatomer protein complex, subunit beta 1 | Copb1 | nd | up |
| coatomer protein complex, subunit epsilon | Cope | nd | up |
| coatomer protein complex, subunit gamma 2 | Copg2 | down | nd |
| chromosome segregation 1-like (S. cerevisiae) | Cse1l | nd | up |
| casein kinase 1, alpha 1 | Csnk1a1 | nd | up |
| casein kinase 1, delta | Csnk1d | up | up |
| dynactin 1 | Dctn1 | nd | down |
| dynein, cytoplasmic, heavy chain 1 | Dnchc1 | nd | down |
| dynein, cytoplasmic, intermediate chain 1 | Dncic1 | nd | up |
| dynamin 1 | Dnm1 | down | nd |
| dynamin 2 | Dnm2 | down | down |
| epimorphin (SYNTAXIN 2) | Epim | up | nd |
| endoplasmic reticulum protein 29 | Erp29 | down | nd |
| exocyst complex component 7 | Exoc7 | up | nd |
| GTPase activating RANGAP domain-like 1 | Garnl1 | nd | down |
| guanosine diphosphate (GDP) dissociation inhibitor 2 | Gdi2 | up | nd |
| guanine nucleotide binding protein-like 2 (nucleolar) | Gnl2 | up | up |
| golgi autoantigen, golgin subfamily a, 3 | Golga3 | down | nd |
| golgi autoantigen, golgin subfamily a, 4 | Golga4 | up | nd |
| GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein | Grasp | down | nd |
| general transcription factor II A, 1-like factor | Gtf2a1 | nd | down |
| general transcription factor II A, 1-like factor | Gtf2a1lf | down | down |
| Huntington disease gene homolog | Hdh | up | nd |
| kinesin family member 20A | Kif20a | nd | up |
| kinesin family member 3B | Kif3b | up | nd |
| kinesin family member 3C | Kif3c | up | nd |
| kinesin family member 5C | Kif5c | nd | down |
| karyopherin (importin) alpha 2 | Kpna2 | nd | down |
| low density lipoprotein receptor-related protein 1 | Lrp1 | down | down |
| mitsugumin 29 | Mg29 | up | up |
| N-ethylmaleimide sensitive fusion protein attachment protein alpha | Napa | up | nd |
| natural killer tumor recognition sequence | Nktr | down | nd |
| neutral sphingomyelinase (N-SMase) activation associated factor | Nsmaf | up | nd |
| nucleoporin 62 | Nup62 | up | up |
| peroxisomal biogenesis factor 3 | Pex3 | up | nd |
| peroxisome biogenesis factor 5 | Pex5 | up | nd |
| peroxisomal biogenesis factor 6 | Pex6 | nd | down |
| phosphatidylinositol transfer protein, membrane-associated 2 | Pitpnm2 | up | up |
| peptidylprolyl isomerase A | Ppia | nd | up |
| peptidylprolyl isomerase C | Ppic | up | nd |
| peptidylprolyl isomerase E (cyclophilin E) | Ppie | down | nd |
| pleckstrin homology, Sec7 and coiled-coil domains 3 | Pscd3 | up | nd |
| PX domain containing serine/threonine kinase | Pxk | up | nd |
| RAB10, member RAS oncogene family | Rab10 | down | down |
| RAB11a, member RAS oncogene family | Rab11a | nd | down |
| RAB11B, member RAS oncogene family | Rab11b | down | down |
| RAB14, member RAS oncogene family | Rab14 | down | nd |
| RAB18, member RAS oncogene family | Rab18 | up | nd |
| RAB37, member of RAS oncogene family | Rab37 | down | nd |
| RAB3C, member RAS oncogene family | Rab3c | nd | down |
| RAB3D, member RAS oncogene family | Rab3d | up | up |
| 1 RAB4A, member RAS oncogene family | Rab4a | up | up |
| RAB5A, member RAS oncogene family | Rab5a | down | nd |
| RAB5B, member RAS oncogene family | Rab5b | down | nd |
| RAB6, member RAS oncogene family | Rab6 | nd | up |
| guanine nucleotide exchange factor (GEF) 1 | Rabgef1 | down | nd |
| RAN binding protein 1 | Ranbp1 | down | nd |
| SAR1a gene homolog 1 (S. cerevisiae) | Sara1 | down | nd |
| secretory carrier membrane protein 2 | Scamp2 | nc | up |
| secretory carrier membrane protein 3 | Scamp3 | nd | up |
| secretory carrier membrane protein 5 | Scamp5 | up | up |
| syndecan binding protein (syntenin) 2 | Sdcbp2 | up | nd |
| SH3 domain protein 1B (INTERSECTIN 2) | Sh3d1B | down | nd |
| synaptosomal-associated protein 23 | Snap23 | down | nd |
| sorting nexin 1 | Snx1 | up | nd |
| sorting nexin 2 | Snx2 | down | down |
| sorting nexin 5 | Snx5 | down | nd |
| sorting nexin 9 | Snx9 | down | nd |
| syntaxin 5A | Stx5a | down | nd |
| syntaxin 6 | Stx6 | down | nd |
| syntaxin 8 | Stx8 | up | nd |
| synaptotagmin 10 | Syt10 | down | up |
| synaptotagmin 8 | Syt8 | nd | down |
| trafficking protein particle complex 4 | Trappc4 | nd | up |
| tubulin, alpha 4 | Tuba4 | nd | up |
| tubulin, beta 3 | Tubb3 | nd | up |
| vesicle-associated membrane protein, associated protein A (Vapa) | Vapa | up | nd |
| vesicle-associated membrane protein 4 | Vamp4 | up | nd |
| vesicle-associated membrane protein 5 | Vamp5 | up | up |
| vesicle-associated membrane protein 8 | Vamp8 | down | nd |
| vesicle-associated membrane protein, associated protein B and C | Vapb | down | nd |
| vesicle docking protein (Interim) | Vdp | nd | up |
| vacuolar protein sorting 4b (yeast) | Vps4b | up | nd |
| visinin-like 1 | Vsnl1 | nd | up |
| vesicle transport through interaction with t-SNAREs 1B homolog | Vti1b | nd | up |
| exportin 7 | Xpo7 | nd | up |
ND not detected; up down reflect upregulation or downregulation by enterostatin.