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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Peptides. 2009 Jul 29;30(10):1892–1900. doi: 10.1016/j.peptides.2009.07.012

Figure 1. Response of melanocortin receptor knockout and diet-induced obese mice to BIM-22493 treatment.

Figure 1

(A) Reduced food intake by BIM-22493 is dependent on MC4R, and not MC3R. Mice were fasted overnight and then given a single ip. injection of BIM-22493 (6.4 μm) 30 min. prior to food presentation. (B) A single injection of BIM-22493 improves glucose tolerance of obese Lepob/Lepob mice. Mice were fasted overnight, and injected with either BIM-22493 (6.4 μm) or saline followed by glucose. *P<0.05 vs control; n=6/group for panels A and B. (C) Weight loss in diet-induced obese B6 mice treated with BIM-22493 (300 nmol/kg/d by subcutaneous osmotic pump for 14 days). (D, E) Food intake expressed as a percent of control (D) or grams per mouse per day (E). Reduced food intake associated with BIM-22493 was most severe prior to day 3. (E) Average daily food intake of controls and treatment group during the treatment period.* P<0.05 vs. control. N=6/group.