Table 3. Blood chemistries of WT, Mc3rKO and Mc4rKO treated with BIM-22511 compared to controls.
* P<0.01 compared to saline treatment within genotype. Serum was collected after a 4h fast.
| Genotype: Treatment: |
WT | Mc3rKO | Mc4rKO | |||
|---|---|---|---|---|---|---|
| Saline | BIM-22511 | Saline | BIM-22511 | Saline | BIM-22511 | |
|
Glucose (mg/dL) |
100 ± 7 | 129 ± 20 | 164 ± 22 | 193 ± 28 | 153 ± 10 | 119 ± 15 |
|
Insulin (pg/ml) |
138 ± 30 | 145 ± 40 | 124 ± 21 | 310 ± 55 | 3588 ± 812 | 1899 ± 160 * |
| HOMA-IR | 0.9 ± 0.2 | 1.3 ± 0.5 | 1.3 ± 0.3 | 3.5 ± 0.5 | 33.5 ± 7.0 | 14.2 ± 3.7 * |
|
TG (mg/dL) |
34 ± 5 | 55 ± 10 | 59 ± 6 | 109 ± 12 * | 61 ± 9 | 70 ± 6 |
|
TC (mg/dL) |
74 ± 9 | 93 ± 11 | 100 ± 2 | 107 ± 7 | 90 ± 9 | 107 ± 1 |
|
NEFA (mEq/L) |
1.12 ± 0.11 | 1.57 ± 0.28 | 1.70 ± 0.11 | 1.92 ± 0.07 | 1.56 ± 0.16 | 1.71 ± 0.15 |
|
Leptin (pg/ml) |
1985 ± 434 | 1645 ± 432 | 2247 ± 739 | 2834 ± 595 | 15582 ± 2294 | 14948 ± 5125 |
|
Resistin (pg/ml) |
1798 ± 127 | 1015 ± 175 * | 1395 ± 209 | 1330 ± 83 | 1749 ± 258 | 2227 ± 202 |