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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: J Immunol. 2009 Jun 19;183(2):1197–1206. doi: 10.4049/jimmunol.0803883

Figure 7.

Figure 7

Model of IL-10-mediated anti-inflammatory effects. IL-10 activates the transcription factor Stat3 that drives the expression of at least three effector genes. The still unidentified repressors of transcription are depicted by question marks. The other effector is TTP that requires the activity of a third effector, the DUSP1 phosphatase, that reduces the activity of p38MAPK thereby increasing the TTP destabilizing activity towards specific ARE-containing mRNAs. The activity of DUSP1 can be mimicked by e.g. the p38MAPK inhibitor SB203580.