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. Author manuscript; available in PMC: 2009 Oct 2.
Published in final edited form as: Eur J Immunol. 2008 Dec;38(12):3450–3458. doi: 10.1002/eji.200838640

Fig. 3. Increased T cell proliferation and cytokine production in APRIL−/− mice.

Fig. 3

A. T cell proliferation was measured by [3H] thymidine incorporation. Splenocytes were cultured at 1×106 cells/ml and stimulated with 0–5μg/ml of anti-CD3 for 3 days. Representative data represent 7 pairs of mice from 5 independent experiments; * p=0.0401; n=7; paired t test. B – M. Cytokine production under ThN, Th1, Th2 and Th17 conditions upon primary (1°) and secondary (2°) stimulation, respectively. For details see Material and Methods. *, p<0.05; **, p<0.01; ***, p<0.001; n=10; paired t test. Data from 6 independent experiments (n=1–3 each) were combined. n.d.- Not done.