Table 1.
Polarization | Cytokine regulation in APRIL−/− versus APRIL+/+ CD4+ T cellsa | |||||
---|---|---|---|---|---|---|
IFN-γ | IL-4 | IL-5 | IL-10 | IL-13 | IL-17 | |
ThN | Up, 2° | Up, 1°+ 2° | Up, 2° | Up, 2° | Up, 2° | none |
Th1 | none | none | none | none | none | none |
Th2 | none | none | none | none | Up, 1°+ 2° | Up, 2° |
Th17 | none | none | none | Down, 1° | none | none |
‘Up’ and ‘Down’ indicates statistically significantly higher or lower cytokine levels, respectively, secreted by APRIL−/− CD4+ T cells compared to APRIL+/+ CD4+ T cells. 1° or 2° indicates change only after primary or secondary stimulation, respectively; 1° + 2° indicates change after either stimulation.